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Hated it! Known For. Indiana Jones and the Last Crusade Fedora. Friday the 13th: A New Beginning Matt. Amazing Stories Davy Crockett. Eye of the Widow Prince Malko Linge.
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Larry Castle. Charles Warner. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes.
S, Day, D. P, Sigova, A. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Weintraub, A. YY1 is a structural regulator of enhancer-promoter loops.
MeCP2 methyl CpG binding protein 2 is a key component of constitutive heterochromatin, which plays important roles in chromosome maintenance and transcriptional silencing.
Mutations in MeCP2 cause Rett syndrome RTT , a postnatal progressive neurodevelopmental disorder associated with severe mental disability and autism-like symptoms that manifests in girls during early childhood.
We found that MeCP2 is a dynamic component of heterochromatin condensates in cells and that both its DNA-binding domain and its C-terminal intrinsically disordered domain contribute to condensate formation Li et al.
MeCP2 manifests physicochemical properties that selectively concentrate heterochromatin cofactors compared to components of transcriptionally active condensates, and when altered by RTT-causing mutations, is disrupted in its ability to form condensates.
We are now studying the properties of nuclear condensate-promoting proteins such as MeCP2 to determine if their physicochemical properties contribute to the separation of euchromatic and heterochromatic condensates, and thereby ensure transcriptional silencing of heterochromatin.
Li, C. MeCP2 links heterochromatin condensates and neurodevelopmental disease. We are scientists with diverse backgrounds and affiliations that bring rich experience to our laboratory and community.
Our collective training is in basic biology, chemistry, physics, computing and medicine. We strive to contribute to our community and advance a new generation of scientific leaders.
Victoria is a senior neurosurgery resident physician at MGH. She is currently performing a research fellowship in the Young lab characterizing the epigenomic drivers of meningioma formation, with the goal of identifying novel medical treatments for patients with brain tumors.
My goal is to identify altered nuclear condensate properties in disease, including cancer and type 2 diabetes. I am a cellular and molecular biologist with an emphasis on human genetics, gene regulation, and the genetic basis of human disease.
My current research goals are to identify the master gene regulatory pathways that control human glial cell identity and state, and to use this information to produce superior stem cell-based models of human glia to study neurodegenerative disease.
I am a stem cell and molecular biologist exploring how RNA regulates biomolecular condensates and gene expression in both native and disease states.
I am interested in quantifying the chemical features and properties underlying the complex thermodynamic and kinetic phenomenon of condensate molecular grammar.
I am a molecular biologist who has a background in gene regulation, chromatin biology and epigenetics. My research focuses on understanding i how RNA regulates transcription by dynamically controlling transcriptional condensates and ii how RNA-mediated control of transcription could be leveraged in treatment of human diseases.
Mediator condensates localize signaling factors to key cell identity genes. Mol Cell Regulation and dysregulation of chromosome structure in cancer.
Ann Rev Cancer Biol. Science , , eaar Schuijers, J. Transcriptional dysregulation of MYC reveals common enhancer-docking mechanism.
Cell Reports Insulated neighborhoods: structural and functional units of mammalian gene control. C, Sharp, P.
Transcription factor trapping by RNA in gene regulatory elements. Wang, Y. Cell — Super-enhancers in the control of cell identity and disease.
The New York Times , October 9, Eliot Coffey, Richard Young. Whitehead Institute, September 8, Richard Young.
Whitehead Institute, August 12, Victoria Clark, Isaac Klein. Whitehead Institute, October 21, Regina Barzilay MIT. Linda Griffith MIT.
Anthony Hyman Max Plank Institute. Wendy Salmon Whitehead. Phillip A. Kimberly Stegmaier Harvard. Tom Volkert Whitehead. Jinghui Zhang St. Thomas Zwaka NYU.
Exploring gene regulation in health and disease. Transcriptional condensates We discovered that large clusters of enhancers, which we call super-enhancers, regulate genes that play the most prominent roles in cell identity Whyte et al.
Drug partitioning in condensates Our studies of super-enhancers and their associated biomolecular condensates have led to new approaches to anti-cancer drugs.
Drug partitioning in condensates Postdocs Isaac Klein and Ann Boija discuss their discovery that cancer therapeutics selectively partition in nuclear condensates.
Chromosome structure and gene regulation Our studies have revealed roles for specific chromosome structures in regulation of gene expression in healthy cells and in cancer.
Heterochromatic condensates and neurodevelopmental disease MeCP2 methyl CpG binding protein 2 is a key component of constitutive heterochromatin, which plays important roles in chromosome maintenance and transcriptional silencing.
Postdoctoral Associates and Fellows. Salman Banani. Ann Boija. Michael Gallagher I am a cellular and molecular biologist with an emphasis on human genetics, gene regulation, and the genetic basis of human disease.
Jon Henninger I am a stem cell and molecular biologist exploring how RNA regulates biomolecular condensates and gene expression in both native and disease states.
Henry Kilgore I am interested in quantifying the chemical features and properties underlying the complex thermodynamic and kinetic phenomenon of condensate molecular grammar.Activity Karten are now investigating how specific functional groups in small molecules provide drugs with the ability to concentrate within specific compartments in cells. Super-enhancers in the control of cell identity and disease. Three years ago, he noticed a gap in the market for a series comprising only fast-structured, high stakes tournaments and established Triton to plug it.